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Attention and Motor Learning in Adult Patients with Neurofibromatosis Type 1.

Authors
  • Castricum, Jesminne1, 2
  • Tulen, Joke H M1, 2
  • Taal, Walter1, 2
  • Rietman, André B2, 3
  • Elgersma, Ype1, 2
  • 1 Erasmus University Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 2 The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC, Rotterdam, the Netherlands. , (Netherlands)
  • 3 Erasmus University Medical Center Sophia Children's Hospital, Rotterdam, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Journal of Attention Disorders
Publisher
SAGE Publications
Publication Date
Feb 01, 2022
Volume
26
Issue
4
Pages
563–572
Identifiers
DOI: 10.1177/10870547211012035
PMID: 33978520
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that is associated with cognitive disabilities, including attention and motor learning problems. These disabilities have been extensively studied in children with NF1 but limited studies have been performed in adults. Attention, motor learning and intellectual performance were studied with neuropsychological tasks in 32 adults with NF1 and 32 controls. The NF1 and control group performed similarly on attention and motor learning tasks, although controls had shorter reaction times than adults with NF1 during the motor learning task (t[60] = -2.20, p = .03). Measures of attention or motor learning were not significantly associated with reduced intellectual performance in NF1. In contrast to many studies in children with NF1, our findings did not provide evidence for presence of attention or motor learning problems in adults with NF1 in neuropsychological tasks. Our observations may be of clinical importance to determine treatment focus in adults with NF1.

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