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Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy: Experience from the Nordic ARVC Registry.

Authors
  • Baturova, Maria A1
  • Haugaa, Kristina H2
  • Jensen, Henrik K3
  • Svensson, Anneli4
  • Gilljam, Thomas5
  • Bundgaard, Henning6
  • Madsen, Trine7
  • Hansen, Jim8
  • Chivulescu, Monica2
  • Christiansen, Morten Krogh9
  • Carlson, Jonas10
  • Edvardsen, Thor2
  • Svendsen, Jesper H6
  • Platonov, Pyotr G10
  • 1 Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; Research Park, Saint Petersburg State University, Saint Petersburg, Russia. Electronic address: [email protected] , (Sweden)
  • 2 Center for Cardiological Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute for Clinical Medicine, University of Oslo, Oslo, Norway. , (Norway)
  • 3 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark. , (Denmark)
  • 4 Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. , (Sweden)
  • 5 Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. , (Sweden)
  • 6 Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 7 Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. , (Denmark)
  • 8 Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 9 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. , (Denmark)
  • 10 Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden. , (Sweden)
Type
Published Article
Journal
International journal of cardiology
Publication Date
Jan 01, 2020
Volume
298
Pages
39–43
Identifiers
DOI: 10.1016/j.ijcard.2019.07.086
PMID: 31387820
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations. Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010. AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001). AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression. Copyright © 2019 Elsevier B.V. All rights reserved.

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