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Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control.

Authors
  • Zhang, Wen-Jin1
  • Zhao, Zhen-Yu2
  • Chang, Li-Kun3
  • Cao, Ye4
  • Wang, Sheng2
  • Kang, Chuan-Zhi2
  • Wang, Hong-Yang5
  • Zhou, Li2
  • Huang, Lu-Qi6
  • Guo, Lan-Ping7
  • 1 State Key Laboratory of Dao-di Herbs Breeding Base, Joint Laboratory of Infinitus (China) Herbs Quality Research, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China. , (China)
  • 2 State Key Laboratory of Dao-di Herbs Breeding Base, Joint Laboratory of Infinitus (China) Herbs Quality Research, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. , (China)
  • 3 Guangdong Pharmaceutical University, Guangzhou, 510006, China. , (China)
  • 4 Anhui University of Chinese Medicine, Hefei, 230012, China. , (China)
  • 5 Hubei University of Chinese Medicine, Wuhan, 430065, China. , (China)
  • 6 State Key Laboratory of Dao-di Herbs Breeding Base, Joint Laboratory of Infinitus (China) Herbs Quality Research, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: [email protected] , (China)
  • 7 State Key Laboratory of Dao-di Herbs Breeding Base, Joint Laboratory of Infinitus (China) Herbs Quality Research, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of ethnopharmacology
Publication Date
Feb 10, 2021
Volume
266
Pages
113415–113415
Identifiers
DOI: 10.1016/j.jep.2020.113415
PMID: 32987126
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Atractylodis Rhizoma (AR), mainly includes Atractylodes lancea (Thunb.) DC. (A. lancea) and Atractylodes chinensis (DC.) Koidz. (A. chinensis) is widely used in East Asia as a diuretic and stomachic drug, for the treatment of rheumatic diseases, digestive disorders, night blindness, and influenza as it contains a variety of sesquiterpenoids and other components of medicinal importance. A systematic summary on the botany, traditional uses, phytochemistry, pharmacology, toxicology, and quality control of AR was presented to explore the future therapeutic potential and scientific potential of this plant. A review of the literature was performed by consulting scientific databases including Google Scholar, Web of Science, Baidu Scholar, Springer, PubMed, ScienceDirect, CNKI, etc. Plant taxonomy was confirmed to the database "The Plant List". Over 200 chemical compounds have been isolated from AR, notably sesquiterpenoids and alkynes. Various pharmacological activities have been demonstrated, especially improving gastrointestinal function and thus allowed to assert most of the traditional uses of AR. The researches on AR are extensive, but gaps still remain. The molecular mechanism, structure-activity relationship, potential synergistic and antagonistic effects of these components need to be further elucidated. It is suggested that further studies should be carried out in the aspects of comprehensive evaluation of the quality of medicinal materials, understanding of the "effective forms" and "additive effects" of the pharmacodynamic substances based on the same pharmacophore of TCM, and its long-term toxicity in vivo and clinical efficacy. Copyright © 2020 Elsevier B.V. All rights reserved.

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