Adenosine triphosphate (ATP) is a molecular unit of energy that drives various processes in the cellular environment. In this Minireview, we discuss the potential of physical and chemical properties of ATP for the development of bio-inspired, synthetic ATP-induced supramolecular systems with dynamic, stimuli-responsive and active assembly characteristics. Molecular design rules for ATP-induced assemblies with various architectures and their stimuli-responsive structural and functional response are categorized. Special attention is given to the immense potential of ATP-fuelled designs in the nascent field of transient/non-equilibrium supramolecular polymerization for the synthesis of lifelike temporally programmable soft materials. Finally, the existing dearth and fate of ATP-driven systems for future challenges are discussed. © 2020 Wiley-VCH GmbH.