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Atmospheric pressure photoionization mass spectrometry of oligodeoxyribonucleotides.

Authors
Type
Published Article
Journal
European journal of mass spectrometry (Chichester, England)
Publication Date
Volume
14
Issue
2
Pages
71–80
Identifiers
DOI: 10.1255/ejms.913
PMID: 18493096
Source
Medline

Abstract

Small oligonucleotides (di- and trimers) were investigated by atmospheric pressure photoionization (APPI) with focus on the fragmentation mechanisms. The fragmentation patterns of these biomolecular ions have been monitored under dopant-assisted photoionization (DA-APPI) conditions. Our results reveal new aspects of the gas- phase chemistry of ions formed from such biomolecules. They illustrate that the reaction between low-energy electrons released from photoionization processes and di- and trinucleotides lies in dissociative electron attachment processes leading to phosphodiester bond cleavages and to the formation of numerous fragments in the ion source. The conditions of DA-APPI, which involve protic solvents and atmospheric pressure conditions, seem to be relevant for the study of radiation damages to biological molecules.

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