Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.
- Authors
- Type
- Published Article
- Journal
- Journal of veterinary internal medicine / American College of Veterinary Internal Medicine
- Publication Date
- Jan 01, 2015
- Volume
- 29
- Issue
- 1
- Pages
- 207–213
- Identifiers
- DOI: 10.1111/jvim.12523
- PMID: 25586673
- Source
- Medline
- Keywords
- License
- Unknown
Abstract
The atlanto-axial abnormalities of the dwarf dogs resemble those encountered in human CPHD patients with an LHX3 mutation. These findings suggest an association between the LHX3 mutation in dogs with CPHD and atlanto-axial malformations. Consequently, pituitary dwarfs should be monitored closely for neurological signs.