Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.

A M W Y Voorbij; B P Meij; L W L van Bruggen; G C M Grinwis; Q E M Stassen; H S Kooistra

doi:10.1111/jvim.12523

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Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.

Authors

Voorbij, A M W Y
Meij, B P
van Bruggen, L W L
Grinwis, G C M
Stassen, Q E M
Kooistra, H S

Type

Published Article

Journal

Journal of veterinary internal medicine / American College of Veterinary Internal Medicine

Publication Date

Jan 01, 2015

Volume

29

Issue

1

Pages

207–213

Identifiers

DOI: 10.1111/jvim.12523

PMID: 25586673

Source

Medline

Keywords

License

Unknown

Abstract

The atlanto-axial abnormalities of the dwarf dogs resemble those encountered in human CPHD patients with an LHX3 mutation. These findings suggest an association between the LHX3 mutation in dogs with CPHD and atlanto-axial malformations. Consequently, pituitary dwarfs should be monitored closely for neurological signs.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/05/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/25586673

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