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Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.

Authors
  • Voorbij, A M W Y
  • Meij, B P
  • van Bruggen, L W L
  • Grinwis, G C M
  • Stassen, Q E M
  • Kooistra, H S
Type
Published Article
Journal
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine
Publication Date
Jan 01, 2015
Volume
29
Issue
1
Pages
207–213
Identifiers
DOI: 10.1111/jvim.12523
PMID: 25586673
Source
Medline
Keywords
License
Unknown

Abstract

The atlanto-axial abnormalities of the dwarf dogs resemble those encountered in human CPHD patients with an LHX3 mutation. These findings suggest an association between the LHX3 mutation in dogs with CPHD and atlanto-axial malformations. Consequently, pituitary dwarfs should be monitored closely for neurological signs.

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