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Atherosclerosis and arteriosclerosis parameters in stroke patients associate with paraoxonase polymorphism and esterase activities.

Authors
  • Shenhar-Tsarfaty, S1
  • Waiskopf, N
  • Ofek, K
  • Shopin, L
  • Usher, S
  • Berliner, S
  • Shapira, I
  • Bornstein, N M
  • Ritov, Y
  • Soreq, H
  • Ben Assayag, E
  • 1 The Institute of Life Sciences and the Edmond and Lily Safra Center of Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. , (Israel)
Type
Published Article
Journal
European journal of neurology
Publication Date
Jun 01, 2013
Volume
20
Issue
6
Pages
891–898
Identifiers
DOI: 10.1111/ene.12074
PMID: 23305304
Source
Medline
License
Unknown

Abstract

Our findings show inverse PON1 activity-carotid atherosclerosis and -cerebral arteriosclerosis association in stroke patients: the lower the PON1 activity the more progressed is the atherosclerotic process and the weaker is the association with AChE activity. Extending previous PON1 genetic studies in stroke populations, our study emphasizes the PON1 activity as a potential anti-atherogenic element and proposes involvement of cholinesterase activities in its effects.

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