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Asymptomatic COVID-19 in a rehabilitation facility: evolution of the presence of nasopharyngeal SARS-CoV-2 and serological antibody responses

  • Harris, BHL
  • Zuhair, M
  • Di Giovannantonio, M
  • Rosadas, C
  • Short, C-E
  • Thaventhiran, T
  • Quinlan, R
  • Taylor, A
  • Calvez, R
  • Taylor, GP
  • Tedder, RS
  • McClure, MO
  • Fertleman, M
Publication Date
Oct 05, 2020
UPCommons. Portal del coneixement obert de la UPC


At the start of the UK COVID-19 epidemic, this rare point prevalence study reveals ⅓ of patients in a London inpatient rehabilitation unit were found to be infected with SARS-CoV 2, but asymptomatic (n=15/45). We report on eight patients in detail, including their clinical stability, the evolution of their nasopharyngeal viral RT-PCR burden and their antibody levels over time revealing the infection dynamics by RT-PCR and serology during the acute phase. Notably, a novel serological test for antibodies against the receptor binding domain of SARS40 CoV-2 (anti-RBD) showed 100% of our asymptomatic cohort remained seropositive between 3 to 6 weeks post-diagnosis.

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