Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Asymmetric temporal integration of layer 4 and layer 2/3 inputs in visual cortex.

Authors
  • Hang, Giao B
  • Dan, Yang
Type
Published Article
Journal
Journal of Neurophysiology
Publisher
American Physiological Society
Publication Date
Jan 01, 2011
Volume
105
Issue
1
Pages
347–355
Identifiers
DOI: 10.1152/jn.00159.2010
PMID: 21068267
Source
Medline
License
Unknown

Abstract

Neocortical neurons in vivo receive concurrent synaptic inputs from multiple sources, including feedforward, horizontal, and feedback pathways. Layer 2/3 of the visual cortex receives feedforward input from layer 4 and horizontal input from layer 2/3. Firing of the pyramidal neurons, which carries the output to higher cortical areas, depends critically on the interaction of these pathways. Here we examined synaptic integration of inputs from layer 4 and layer 2/3 in rat visual cortical slices. We found that the integration is sublinear and temporally asymmetric, with larger responses if layer 2/3 input preceded layer 4 input. The sublinearity depended on inhibition, and the asymmetry was largely attributable to the difference between the two inhibitory inputs. Interestingly, the asymmetric integration was specific to pyramidal neurons, and it strongly affected their spiking output. Thus via cortical inhibition, the temporal order of activation of layer 2/3 and layer 4 pathways can exert powerful control of cortical output during visual processing.

Report this publication

Statistics

Seen <100 times