Affordable Access

deepdyve-link
Publisher Website

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain.

Authors
  • Verkhratsky, Alexei1, 2, 3
  • Augusto-Oliveira, Marcus4
  • Pivoriūnas, Augustas5
  • Popov, Alexander6
  • Brazhe, Alexey6, 7
  • Semyanov, Alexey8, 9
  • 1 Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. [email protected]
  • 2 Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain. [email protected] , (Spain)
  • 3 Department of Neurosciences, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain. [email protected] , (Spain)
  • 4 Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, 66075-110, Brazil. , (Brazil)
  • 5 Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01102, Vilnius, Lithuania. , (Lithuania)
  • 6 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya street 16/10, Moscow, Russia, 117997.
  • 7 Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
  • 8 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya street 16/10, Moscow, Russia, 117997. [email protected]
  • 9 Sechenov First Moscow State Medical University, Moscow, Russia. [email protected]
Type
Published Article
Journal
Pflügers Archiv - European Journal of Physiology
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
473
Issue
5
Pages
753–774
Identifiers
DOI: 10.1007/s00424-020-02465-3
PMID: 32979108
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Astroglia represent a class of heterogeneous, in form and function, cells known as astrocytes, which provide for homoeostasis and defence of the central nervous system (CNS). Ageing is associated with morphological and functional remodelling of astrocytes with a prevalence of morphological atrophy and loss of function. In particular, ageing is associated with (i) decrease in astroglial synaptic coverage, (ii) deficits in glutamate and potassium clearance, (iii) reduced astroglial synthesis of synaptogenic factors such as cholesterol, (iv) decrease in aquaporin 4 channels in astroglial endfeet with subsequent decline in the glymphatic clearance, (v) decrease in astroglial metabolic support through the lactate shuttle, (vi) dwindling adult neurogenesis resulting from diminished proliferative capacity of radial stem astrocytes, (vii) decline in the astroglial-vascular coupling and deficient blood-brain barrier and (viii) decrease in astroglial ability to mount reactive astrogliosis. Decrease in reactive capabilities of astroglia are associated with rise of age-dependent neurodegenerative diseases. Astroglial morphology and function can be influenced and improved by lifestyle interventions such as intellectual engagement, social interactions, physical exercise, caloric restriction and healthy diet. These modifications of lifestyle are paramount for cognitive longevity.

Report this publication

Statistics

Seen <100 times