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Astrocyte´s RAGE: More Than Just a Question of Mood.

Authors
  • Gonzalez-Reyes, Rodrigo E1
  • Rubiano, Maria G1
  • 1 Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Narino, Bogota, Colombia. , (Colombia)
Type
Published Article
Journal
Central nervous system agents in medicinal chemistry
Publication Date
Jan 26, 2018
Volume
18
Issue
1
Pages
39–48
Identifiers
DOI: 10.2174/1871524916999160505105121
PMID: 27149992
Source
Medline
Keywords
License
Unknown

Abstract

It is plausible that a prolonged exposure to RAGE ligands or abnormally increased concentrations of some ligands may induce lengthy periods of intracellular proinflammatory activation, which may induce the appearance of reactive astrocytes involved in the development and/or progression of neurodegenerative disorders. Blocking or reducing the duration of activation of RAGE/NF-κB signaling in astrocytes may become an important therapeutic alternative for the treatment of neurodegenerative disorders in the future.

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