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Asthma phenotypes in childhood.

Authors
  • Deliu, Matea1
  • Belgrave, Danielle2
  • Sperrin, Matthew1
  • Buchan, Iain1
  • Custovic, Adnan2
  • 1 a Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health , University of Manchester , Manchester , UK.
  • 2 b Department of Paediatrics , Imperial College of Science, Technology & Medicine , London , UK.
Type
Published Article
Journal
Expert Review of Clinical Immunology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jul 01, 2017
Volume
13
Issue
7
Pages
705–713
Identifiers
DOI: 10.1080/1744666X.2017.1257940
PMID: 27817211
Source
Medline
Keywords
License
Unknown

Abstract

Asthma is no longer thought of as a single disease, but rather a collection of varying symptoms expressing different disease patterns. One of the ongoing challenges is understanding the underlying pathophysiological mechanisms that may be responsible for the varying responses to treatment. Areas Covered: This review provides an overview of our current understanding of the asthma phenotype concept in childhood and describes key findings from both conventional and data-driven methods. Expert Commentary: With the vast amounts of data generated from cohorts, there is hope that we can elucidate distinct pathophysiological mechanisms, or endotypes. In return, this would lead to better patient stratification and disease management, thereby providing true personalised medicine.

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