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Asthma increases the risk of herpes zoster: a nested case–control study using a national sample cohort

Authors
  • Kim, So Young1
  • Oh, Dong Jun2
  • Choi, Hyo Geun3, 4
  • 1 CHA Bundang Medical Center, CHA University, Seongnam, South Korea , Seongnam (South Korea)
  • 2 Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea , Seoul (South Korea)
  • 3 Hallym University College of Medicine, Sacred Heart Hospital, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-Si, Gyeonggi-do, 14068, Republic of Korea , Anyang-Si (South Korea)
  • 4 Hallym University College of Medicine, Anyang, Republic of Korea , Anyang (South Korea)
Type
Published Article
Journal
Allergy, Asthma & Clinical Immunology
Publisher
BioMed Central
Publication Date
Jun 23, 2020
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s13223-020-00453-x
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThis study aimed to complement previous studies on the risk of herpes zoster in the asthmatic adult population.MethodsThe Korean Health Insurance Review and Assessment Service—National Sample Cohort (HIRA-NSC) from 2002 through 2013 was used. A total of 64,152 participants with herpes zoster were matched for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 239,780 participants who were included as a control group. In both the herpes zoster and control groups, previous history of asthma were investigated. The crude and adjusted odds ratios (ORs) and 95% confidence intervals (CI) of asthma for herpes zoster were analyzed using unconditional logistic regression analysis. Subgroup analyses were conducted according to age and sex.ResultsApproximately 16.2% (9728/59,945) and 12.8% (30,752/239,780) of participants in the herpes zoster and control groups, respectively, had a previous history of asthma (P < 0.001). The herpes zoster group demonstrated a 1.32-times higher odds of asthma than the control group (95% CI 1.28–1.35, P < 0.001). The increased odds of asthma in the herpes zoster group persisted in all the age and sex subgroups.ConclusionsThe odds for asthma were higher in the herpes zoster group.

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