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Asthma increases the risk of herpes zoster: a nested case–control study using a national sample cohort

  • Kim, So Young1
  • Oh, Dong Jun2
  • Choi, Hyo Geun3, 4
  • 1 CHA Bundang Medical Center, CHA University, Seongnam, South Korea , Seongnam (South Korea)
  • 2 Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea , Seoul (South Korea)
  • 3 Hallym University College of Medicine, Sacred Heart Hospital, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-Si, Gyeonggi-do, 14068, Republic of Korea , Anyang-Si (South Korea)
  • 4 Hallym University College of Medicine, Anyang, Republic of Korea , Anyang (South Korea)
Published Article
Allergy, Asthma & Clinical Immunology
BioMed Central
Publication Date
Jun 23, 2020
DOI: 10.1186/s13223-020-00453-x
Springer Nature


BackgroundThis study aimed to complement previous studies on the risk of herpes zoster in the asthmatic adult population.MethodsThe Korean Health Insurance Review and Assessment Service—National Sample Cohort (HIRA-NSC) from 2002 through 2013 was used. A total of 64,152 participants with herpes zoster were matched for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 239,780 participants who were included as a control group. In both the herpes zoster and control groups, previous history of asthma were investigated. The crude and adjusted odds ratios (ORs) and 95% confidence intervals (CI) of asthma for herpes zoster were analyzed using unconditional logistic regression analysis. Subgroup analyses were conducted according to age and sex.ResultsApproximately 16.2% (9728/59,945) and 12.8% (30,752/239,780) of participants in the herpes zoster and control groups, respectively, had a previous history of asthma (P < 0.001). The herpes zoster group demonstrated a 1.32-times higher odds of asthma than the control group (95% CI 1.28–1.35, P < 0.001). The increased odds of asthma in the herpes zoster group persisted in all the age and sex subgroups.ConclusionsThe odds for asthma were higher in the herpes zoster group.

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