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Astakine1 forms protein complex in plasma.

Authors
  • Sirikharin, Ratchanok1
  • Noonin, Chadanat1
  • Junkunlo, Kingkamon1
  • Söderhäll, Kenneth2
  • Söderhäll, Irene3
  • 1 Department of Comparative Physiology, Uppsala University, Norbyvägen 18 A, SE752 36, Uppsala, Sweden. , (Sweden)
  • 2 Science for Life Laboratory, Department of Comparative Physiology, Uppsala University, Norbyvägen 18A, 752 36, Uppsala, Sweden. , (Sweden)
  • 3 Science for Life Laboratory, Department of Comparative Physiology, Uppsala University, Norbyvägen 18A, 752 36, Uppsala, Sweden. Electronic address: [email protected] , (Sweden)
Type
Published Article
Journal
Fish & Shellfish Immunology
Publisher
Elsevier
Publication Date
Nov 01, 2019
Volume
94
Pages
66–71
Identifiers
DOI: 10.1016/j.fsi.2019.08.063
PMID: 31465872
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Astakine 1 is a small cytokine-like peptide which is directly involved in hematopoiesis in crustaceans. Astakines are present in many different invertebrate groups primarily in arthropods. In this study we found that astakine1 was present as a high molecular weight (HMW) complex in plasma. It is known that calcium concentration are fluctuating in several crustaceans especially during the molting process. This HMW-complex was formed under low calcium concentrations in plasma and could be partially reversed provided calcium was added. The biological function of the naïve astakine1 and that in the HMW complex was about the same, but if the protein is to be isolated or studied for its function it is important to know about this property of astakine1 which may previously have hampered isolation and functional studies in other animals than freshwater crayfish. Copyright © 2019 Elsevier Ltd. All rights reserved.

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