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Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss

Authors
  • Zhao, Tianyu1, 2
  • Wang, Yinan1
  • Li, Zheng1
  • Xu, Xiaojun1
  • Lei, Song3
  • Huang, Liu1
  • Xu, Liangwen1
  • Zhang, Meibian4
  • Yang, Lei1
  • 1 Hangzhou Normal University, Hangzhou, 310000, China , Hangzhou (China)
  • 2 Shihezi University, Shihezi, 832000, China , Shihezi (China)
  • 3 Ningbo Center for Disease Control and Prevention, Ningbo, 315700, China , Ningbo (China)
  • 4 Institute of Occupational Health and Radiation Protection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310000, China , Hangzhou (China)
Type
Published Article
Journal
Environmental Health
Publisher
BioMed Central
Publication Date
Feb 03, 2020
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12940-020-0566-3
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundNoise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study was to explore the association of noise kurtosis, triphosphopyridine nucleotide oxidase 3 (NOX3) and lifestyles with NIHL.MethodsThis case-control study included 307 patients with NIHL and 307 matched control individuals from Zhejiang province of China. General characteristics, noise exposure data, the exfoliated cells of the oral mucosa, and lifestyle details of individuals were collected. The kompetitive allele specific polymerase chain reaction (KASP) method was used to analyze the genotypes of three single nucleotide polymorphisms (SNPs) of NOX3.ResultsPeople who exposed to complex noise had a higher risk of NIHL than those exposed to steady noise (adjusted: OR = 1.806, P = 0.002). The GT genotype of additive model and TT + GT genotype of dominant model in NOX3 rs12195525 decreased the risk of NIHL (adjusted: OR = 0.618, P = 0.043; OR = 0.622, P = 0.036). Smoking and exposure to high video volume increased the risk of NIHL (adjusted: OR = 1.486, P = 0.038; OR = 1.611, P = 0.014). Oppositely, regular physical exercise decreased the risk of NIHL (adjusted: OR = 0.598, P = 0.004). A positive interaction was found between complex noise and lifestyles including high video volume exposure and no physical exercise in the additive models (RERI = 1.088, P < 0.001; RERI = 1.054, P = 0.024). A positive interaction was also found between NOX3 rs12195525 GG genotype and lifestyles including smoking and high video volume exposure in the additive models (RERI = 1.042, P = 0.005; RERI = 0.774, P = 0.044).ConclusionsNoise temporal structure, NOX3 rs12195525 polymorphism, and the three lifestyles of smoking, video volume, and physical exercise were related to the NIHL. There were the interactions between noise temporal structure and the lifestyle of video volume or physical exercise, as well as between NOX3 and the lifestyle of smoking or video volume. These results provide a theoretical basis for the prevention and genetic testing of NIHL.

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