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Associations of Newborn Brain Magnetic Resonance Imaging with Long-Term Neurodevelopmental Impairments in Very Preterm Children.

Authors
  • Anderson, Peter J1
  • Treyvaud, Karli2
  • Neil, Jeffrey J3
  • Cheong, Jeanie L Y4
  • Hunt, Rodney W5
  • Thompson, Deanne K6
  • Lee, Katherine J6
  • Doyle, Lex W7
  • Inder, Terrie E8
  • 1 Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia; Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. Electronic address: [email protected] , (Australia)
  • 2 Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Psychology and Counseling, La Trobe University, Melbourne, Victoria, Australia. , (Australia)
  • 3 Department of Neurology, Boston Children's Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.
  • 4 Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Obstetrics and Gynecology, The University of Melbourne, Melbourne, Victoria, Australia; Newborn Intensive Care, The Royal Women's Hospital, Melbourne, Victoria, Australia. , (Australia)
  • 5 Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia; Neonatal Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia. , (Australia)
  • 6 Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia. , (Australia)
  • 7 Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Obstetrics and Gynecology, The University of Melbourne, Melbourne, Victoria, Australia; Newborn Intensive Care, The Royal Women's Hospital, Melbourne, Victoria, Australia; Department of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia. , (Australia)
  • 8 Harvard Medical School, Harvard University, Boston, MA; Pediatric Newborn Medicine, The Brigham and Women's Hospital, Boston, MA.
Type
Published Article
Journal
The Journal of pediatrics
Publication Date
Aug 01, 2017
Volume
187
Identifiers
DOI: 10.1016/j.jpeds.2017.04.059
PMID: 28583705
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum. Children were assessed at 7 years on measures of general intelligence, motor functioning, academic achievement, and behavior. One hundred eighty-six very preterm children (83%) had both an MRI at term equivalent age and a 7-year follow-up assessment. Higher global brain, cerebral white matter, and deep gray matter abnormality scores were related to poorer intelligence quotient (IQ) (Ps < .01), spelling (Ps < .05), math computation (Ps < .01), and motor function (Ps < .001). Higher cerebellum abnormality scores were related to poorer IQ (P = .001), math computation (P = .018), and motor outcomes (P = .001). Perinatal, neonatal, and social confounders had little effect on the relationships between the MRI abnormality scores and outcomes. Moderate-severe global abnormality on newborn MRI was associated with a reduction in IQ (-6.9 points), math computation (-7.1 points), and motor (-1.9 points) scores independent of the other potential confounders. Structured evaluation of brain MRI at term equivalent is predictive of outcome at 7 years of age, independent of clinical and social factors. Copyright © 2017 Elsevier Inc. All rights reserved.

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