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Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma.

Authors
  • Sidaraite, Agne1
  • Liutkeviciene, Rasa2, 3
  • Glebauskiene, Brigita3
  • Vilkeviciute, Alvita2
  • Kriauciuniene, Loresa2, 3
  • 1 Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania. , (Lithuania)
  • 2 Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania. , (Lithuania)
  • 3 Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, Kaunas, Lithuania. , (Lithuania)
Type
Published Article
Journal
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
Publication Date
Jun 01, 2020
Volume
164
Issue
2
Pages
189–195
Identifiers
DOI: 10.5507/bp.2019.016
PMID: 31012439
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim was to evaluate the association of CETP (rs5882 and rs708272) single nucleotide polymorphisms with the presence, invasiveness, hormonal activity and recurrence of pituitary adenoma (PA). The study group included 142 patients with PA and the control group, 753 healthy subjects. The genotyping of CETP (rs5882 and rs708272) was performed using a real-time PCR method. After statistical analysis we found that CETP rs708272 genotype G/A under the over-dominant model was associated with the decreased odds of PA (OR=0.637; 95%CI: 0.443-0.917; P=0.015), active PA (OR=0.538; 95%CI: 0.335-0.865; P =0.01) and non-recurrent PA (OR=0.602; 95% CI: 0.402 - 0.902; P =0.014). When compared to controls, the rs708272 genotype G/A was less frequent in the active PA subgroup (37.5% vs 52.7%, P =0.009) and the non-recurrent PA subgroup (40.2% vs 52.7%, P=0.013), while the rs5882 genotype A/A was less frequent in the non-recurrent PA subgroup (37.5% vs 46.2%, P=0.015). Our study showed that CETP rs708272 genotype G/A may be associated with a decreased risk of PA.

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