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Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study.

Authors
  • Lanois, C J1
  • Collins, N2
  • Neogi, T3
  • Guermazi, A3
  • Roemer, F W4
  • LaValley, M5
  • Nevitt, M6
  • Torner, J7
  • Lewis, C E8
  • Stefanik, J J9
  • 1 Northeastern University, Boston, MA, United States. , (United States)
  • 2 The University of Queensland, Brisbane, Australia. , (Australia)
  • 3 Boston University, Chobanian & Avedisian School of Medicine, Boston, MA, United States. , (United States)
  • 4 Friedrich-Alexander University Erlangen-Nurnber, Erlangen, Germany. , (Germany)
  • 5 Boston University, School of Public Health, Boston, MA, United States. , (United States)
  • 6 University of California San Francisco, San Francisco, CA, United States. , (United States)
  • 7 University of Iowa, Iowa City, IA, United States. , (United States)
  • 8 University of Alabama at Birmingham, Birmingham, AL, United States. , (United States)
  • 9 Northeastern University, Boston, MA, United States. Electronic address: [email protected]. , (United States)
Type
Published Article
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier
Publication Date
Jan 01, 2024
Volume
32
Issue
1
Pages
93–97
Identifiers
DOI: 10.1016/j.joca.2023.09.008
PMID: 37783341
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening patellofemoral (PF) cartilage over two years. Participants were recruited from the Multicenter Osteoarthritis Study, a longitudinal study of individuals with or at risk for knee osteoarthritis (OA). Exclusion criteria included bilateral knee replacements, arthritis other than OA, and radiographic PFOA. At baseline, participants completed a knee pain map questionnaire and underwent knee magnetic resonance imaging (MRI). Imaging was repeated at 2-year follow-up. Exposure was presence of frequent AKP. Outcome was worsening cartilage damage in the PF joint defined as increase in MRI Osteoarthritis Knee Score from baseline to 2 years. Log-binomial models were used to calculate risk ratios (RR). One knee from 1083 participants (age 56.7 ± 6.6 years; body mass index 28.0 ± 4.9 kg/m2) was included. Frequent AKP and frequent isolated AKP were present at baseline in 14.5% and 3.6%, respectively. Frequent AKP was associated with an increased risk (RR: 1.78, 95% confidence interval: 1.21, 2.62) of 2-year worsening cartilage damage in the lateral PF compartment. No association was found between frequent AKP and worsening in the medial PF joint. Frequent AKP at baseline was associated with worsening cartilage damage in the lateral PF joint over 2 years. Copyright © 2023 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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