Affordable Access

Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.

Authors
  • Badrising, U A
  • Schreuder, G M Th
  • Giphart, M J
  • Geleijns, K
  • Verschuuren, J J G M
  • Wintzen, A R
  • Maat-Schieman, M L C
  • van Doorn, P
  • van Engelen, B G M
  • Faber, C G
  • Hoogendijk, J E
  • de Jager, A E
  • Koehler, P J
  • de Visser, M
  • van Duinen, S G
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Dec 28, 2004
Volume
63
Issue
12
Pages
2396–2398
Identifiers
PMID: 15623710
Source
Medline
License
Unknown

Abstract

Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.

Report this publication

Statistics

Seen <100 times