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Associations Among Physical Activity, Adiposity, and Insulin Resistance in Children Exposed In Utero to Maternal Obesity With and Without Gestational Diabetes.

Authors
  • Moore, Bethany A1
  • Callahan, Makenzie L1
  • Martin, Samantha L1
  • Everett, Alysha1
  • Garvey, W Timothy1
  • Chandler-Laney, Paula1
  • 1 Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL,USA.
Type
Published Article
Journal
Pediatric exercise science
Publication Date
Aug 01, 2023
Volume
35
Issue
3
Pages
165–173
Identifiers
DOI: 10.1123/pes.2021-0222
PMID: 36543176
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Investigate whether obesity risk and current weight status are independently associated with physical activity (PA) and whether PA is associated with adiposity and insulin resistance (homeostatic model assessment of insulin resistance) among children with high versus low obesity risk based on in utero exposure to maternal overweight/obesity with gestational diabetes mellitus (GDM; high risk) or without GDM (overweight/obesity; high risk) or maternal normal weight without GDM (low risk). Secondary analysis of data from children born to women with overweight/obesity and GDM, overweight/obesity without GDM, or normal weight without GDM. PA was assessed with accelerometry, percentage of body fat derived from anthropometrics, and homeostatic model assessment of insulin resistance calculated from glucose and insulin. Among 4- to 10-year-old children (N = 163), analyses of covariance showed that children with a current BMI ≥85th percentile had less vigorous PA than those with BMI <85th percentile, but in utero exposure was not an independent predictor of PA. In linear regression modeling, moderate to vigorous PA was inversely associated with percentage of body fat and homeostatic model assessment of insulin resistance independent of age, Tanner stage, and accelerometer wear time, with stronger associations in high-risk groups. Children's PA is related to current weight status but not underlying risk for obesity but may be especially important to reduce obesity and insulin resistance in high-risk children.

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