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The associations among lead exposure, bone mineral density, and FRAX score: NHANES, 2013 to 2014.

Authors
  • Wang, Wei-Jie1
  • Wu, Chang-Chin2
  • Jung, Wei-Ting3
  • Lin, Chien-Yu4
  • 1 Division of Nephrology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 300, Taiwan; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan 300, Taiwan. , (Taiwan)
  • 2 Department of Orthopedics, En Chu Kong Hospital, New Taipei City 237, Taiwan; Department of Biomedical Engineering, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan; Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei 106, Taiwan; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei 106, Taiwan. , (Taiwan)
  • 3 Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan. , (Taiwan)
  • 4 School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan; Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan; Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan. Electronic address: [email protected] , (Taiwan)
Type
Published Article
Journal
Bone
Publication Date
Nov 01, 2019
Volume
128
Pages
115045–115045
Identifiers
DOI: 10.1016/j.bone.2019.115045
PMID: 31446117
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Lead exposure has been suspected as a risk factor for osteoporosis. However, in epidemiological studies, the association between environmental lead exposure and bone health were inconsistent. With the decrease of lead exposure in recent decades, we evaluated the association between lead exposure and bone mineral density (BMD) in the general US population in this study. We analyzed data on 1859 adults (aged ≥40 years) from the National Health and Nutrition Examination Survey (NHANES) conducted in 2013-2014 to determine the relationship among lead exposure measured by both blood and urine lead concentration, BMD of total spine and femur, and FRAX score in a cross-sectional study. In premenopausal women, the results showed a 1-unit increase in natural log-transformed blood and urine lead levels was associated with a decrease in total femur BMD of 0.061 g/cm2 (S.E. = 0.015; p = 0.001) and 0.046 g/cm2 (S.E. = 0.018; p = 0.020), respectively. Moreover, in premenopausal women, a 1-unit increase in natural log-transformed blood level was associated with a decrease in total spine BMD of 0.054 g/cm2 (S.E. = 0.019; p = 0.013). Both FRAX scores were positively correlated with blood and urine lead levels in subjects without fractures, while the 10-year hip fracture risk score was positively associated with lead exposure in subjects with a history of fracture or vertebral fracture. In conclusion, lead exposure was associated with decreased total femur and spine BMD, and FRAX score in the general US population. Further research is needed to elucidate the causal relationship among lead exposure, BMD, and fracture risk. Copyright © 2019 Elsevier Inc. All rights reserved.

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