Affordable Access

Publisher Website

Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV.

Authors
  • Lai, Mason1, 2
  • Madden, Erin1, 3
  • Shlipak, Michael G1, 2, 3
  • Scherzer, Rebecca1, 3
  • Post, Wendy S4, 5
  • Vittinghoff, Eric1
  • Haberlen, Sabina5
  • Brown, Todd T6
  • Wolinsky, Steven M7
  • Witt, Mallory D8
  • Ho, Ken9
  • Abraham, Alison G10
  • Parikh, Chirag R11
  • Budoff, Matthew8
  • Estrella, Michelle M1, 3, 12
  • 1 Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco.
  • 2 Department of Medicine, University of California San Francisco.
  • 3 San Francisco VA Healthcare System, San Francisco, California.
  • 4 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine.
  • 5 Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health.
  • 6 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • 7 Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • 8 Lundquist Institute of Biomedical Research at Harbor-UCLA Medical Center, Torrance, California.
  • 9 Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • 10 Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado.
  • 11 Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • 12 Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, California, USA.
Type
Published Article
Journal
AIDS (London, England)
Publication Date
Mar 15, 2024
Volume
38
Issue
4
Pages
465–475
Identifiers
DOI: 10.1097/QAD.0000000000003761
PMID: 37861689
Source
Medline
Language
English
License
Unknown

Abstract

The aim of this study was to determine whether urine biomarkers of kidney health are associated with subclinical cardiovascular disease among men with and without HIV. A cross-sectional study within the Multicenter AIDS Cohort Study (MACS) among 504 men with and without HIV infection who underwent cardiac computed tomography scans and had urine biomarkers measured within the preceding 2 years. Our primary predictors were four urine biomarkers of endothelial (albuminuria), proximal tubule dysfunction (alpha-1-microglobulin [A1 M] and injury (kidney injury molecule-1 [KIM-1]) and tubulointerstitial fibrosis (pro-collagen-III N-terminal peptide [PIIINP]). These were evaluated for association with coronary artery calcium (CAC) prevalence, CAC extent, total plaque score, and total segment stenosis using multivariable regression. Of the 504 participants, 384 were men with HIV (MWH) and 120 were men without HIV. In models adjusted for sociodemographic factors, cardiovascular disease risk factors, eGFR, and HIV-related factors, each two-fold higher concentration of albuminuria was associated with a greater extent of CAC (1.35-fold higher, 95% confidence interval 1.11-1.65), and segment stenosis (1.08-fold greater, 95% confidence interval 1.01-1.16). Associations were similar between MWH and men without HIV in stratified analyses. The third quartile of A1 M showed an association with greater CAC extent, total plaque score, and total segment stenosis, compared with the lowest quartile. Worse endothelial and proximal tubule dysfunction, as reflected by higher urine albumin and A1 M, were associated with greater CAC extent and coronary artery stenosis. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times