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Association of thromboxane B2 production to hypoxemic periods during sleep in male stroke patients.

Authors
Type
Published Article
Journal
Journal of Stroke and Cerebrovascular Diseases
1052-3057
Publisher
Elsevier
Publication Date
Volume
3
Issue
3
Pages
145–149
Identifiers
DOI: 10.1016/S1052-3057(10)80153-3
PMID: 26487353
Source
Medline
License
Unknown

Abstract

To evaluate the possible association between sleep apneas and platelet function, we recorded sleep-related hypoxemic periods and measured platelet thromboxane B2 release in 10 male patients with a previous brain infarction. Four of them revealed an increased morning release of thromboxane B2 compared with the night before, whereas six had an opposite situation. Those with an increased morning release revealed more hypoxemic episodes during the night than the others (median numbers were 58.5 and 2, respectively; p = 0.031), suggesting that sleep apneas may influence platelet function among male stroke victims. This finding might be involved in the suggested role of obstructive sleep apnea syndrome as a risk factor for ischemic stroke as well as the peaking of ischemic strokes in the early morning hours.

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