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Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes.

Authors
  • Redondo, Maria J
  • Muniz, Jesse
  • Rodriguez, Luisa M
  • Iyer, Dinakar
  • Vaziri-Sani, Fariba
  • Haymond, Morey W
  • Hampe, Christiane S
  • Metzker, Michael L
  • Grant, Struan F A
  • Balasubramanyam, Ashok
Type
Published Article
Journal
BMJ Open Diabetes Research & Care
Publisher
BMJ
Publication Date
Jan 01, 2014
Volume
2
Issue
1
Identifiers
DOI: 10.1136/bmjdrc-2013-000008
PMID: 25452857
Source
Medline
Keywords
License
Unknown

Abstract

These results suggest that, in children with only mild islet autoimmunity, mechanisms associated with TCF7L2 genetic variation contribute to diabetogenesis, and this contribution is larger in the absence of obesity.

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