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An association study between FokI, BsmI, miR-146a, and miR-155 and Behcet’s disease in the Egyptian population

  • Emara, Mohamed M.1
  • Mahmoud, Maiada M.2
  • Saad, Mohamed N.3
  • Mabrouk, Mai S.4
  • Hamed, Mohamed5
  • Shaker, Olfat G.6
  • 1 Computer Science Department, Arab Academy for Science, Technology and Maritime Transport, Cairo, Egypt , Cairo (Egypt)
  • 2 Software Engineering Department, Arab Academy for Science, Technology and Maritime Transport, Cairo, Egypt , Cairo (Egypt)
  • 3 Minia University, Minia, Egypt , Minia (Egypt)
  • 4 Misr University for Science and Technology, 6th of October City, Egypt , 6th of October City (Egypt)
  • 5 Institute for Biostatistics and Informatics in Medicine and Ageing Research (IBIMA), Rostock University Medical Center, University of Rostock, Rostock, 18057, Germany , Rostock (Germany)
  • 6 Cairo University, Giza, Egypt , Giza (Egypt)
Published Article
Egyptian Journal of Medical Human Genetics
Springer Berlin Heidelberg
Publication Date
May 21, 2021
DOI: 10.1186/s43042-021-00166-9
Springer Nature


BackgroundBehcet’s disease (BD) is a systemic inflammatory disease of the blood vessels and affects various body parts. This study aimed to determine the association of four single-nucleotide polymorphisms (SNPs) and BD in the Egyptian population using multiple statistical models and show the resulting associations along with previous studies of different populations. Four SNPs were examined for their association with BD: two SNPs from vitamin D receptor gene (FokI and BsmI) were selected and the other two were selected from miR-146a and miR-155. These four SNPs were selected for their association and role with BD in different populations and in the immune system. A marker check was conducted using the Hardy-Weinberg equilibrium and minor allele frequency. The associations were tested using four different statistical models: multiplicative, dominant, recessive, and codominant models. All statistical models used the odd’s ratio (OR) with confidence interval (CI) of 95% to evaluate the association of each SNP.ResultsBsmI showed association using the four models, while FokI did not show any association through any model. miR-155 showed association using the multiplicative and recessive models. miR-146a showed association using the multiplicative model only.ConclusionsAs a result, BsmI, miR-155, and miR-146a SNPs could have a role in the development of BD in the Egyptian population, while FokI could have a weak role, if any, in the development of BD in the Egyptian population.

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