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Association of Sleep Duration with Stroke in Diabetic Patients: Analysis of the National Health Interview Survey.

  • Akinseye, Oluwaseun A1
  • Ojike, Nwakile I2
  • Akinseye, Leah I3
  • Dhandapany, Perundurai S4
  • Pandi-Perumal, Seithikurippu R5
  • 1 Department of Internal Medicine, Queens Hospital Center, Icahn School of Medicine at Mount Sinai, Jamaica, New York; CUNY School of Public Health at Brooklyn College, New York, New York. Electronic address: [email protected] , (Jamaica)
  • 2 Department of Population Health, Center for Behavioral Healthful Change, NYU School of Medicine, New York, New York.
  • 3 CUNY School of Public Health at Brooklyn College, New York, New York.
  • 4 The Knight Cardiovascular Institute, Departments of Medicine, Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon; Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India. , (India)
  • 5 Department of Health & Nutrition Sciences, Somnogen Canada Inc., Toronto, Ontario, Canada. , (Canada)
Published Article
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Publication Date
Mar 01, 2016
DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.023
PMID: 26738814


Habitual sleep duration is increasingly being recognized as an important risk factor for stroke. We sought to describe the association between sleep duration and stroke in a cohort of individuals with diabetes. Data from the National Health Interview Survey for the years 2004-2013 were used. Only those answering "yes" to the question "Have you EVER been told by a doctor or other health professional that you have diabetes or sugar diabetes?" were included in the analysis. Sleep duration was categorized as short (≤6 hours), normal (7-8 hours), or long (≥9 hours). Self-reported diagnosis of stroke was the main outcome of interest. A total number of 26,364 self-reported diabetic individuals provided data for analysis. Stroke was reported in 9.1% of short sleepers, 16.1% of long sleepers, and 8.3% of normative sleepers (P < .05). In the unadjusted model, short and long sleepers had an increased odds of stroke compared to normal sleepers (odds ratio [OR] = 1.12, 95% confidence interval [CI]: 1.02-1.23, P = .01; and OR = 2.18, 95% CI: 1.96-2.42, P = .01; respectively), but the association between short sleep and stroke became nonsignificant after multivariate adjustment (OR = 1.15, 95% CI: .95-1.40, P = .16) except in white participants. The association between long sleep duration and stroke persisted (OR = 1.46, 95% CI: 1.16-1.84, P = .01), especially in males (OR = 1.62, 95% CI: 1.14-2.28) and in white participants (OR = 1.97, 95% CI: 1.47-2.65). In diabetic patients, abnormal sleep duration was associated with increased risk of stroke, and this association varied among different sex and ethnic groups. Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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