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Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.

Authors
  • Asken, Breton M1
  • Mantyh, William G2
  • La Joie, Renaud2
  • Strom, Amelia2
  • Casaletto, Kaitlin B2
  • Staffaroni, Adam M2
  • Apple, Alexandra C2
  • Lindbergh, Cutter A2
  • Iaccarino, Leonardo2
  • You, Michelle2
  • Grant, Harli2
  • Fonseca, Corrina2
  • Windon, Charles2
  • Younes, Kyan2
  • Tanner, Jeremy2
  • Rabinovici, Gil D3
  • Kramer, Joel H2
  • Gardner, Raquel C2, 4
  • 1 Department of Neurology Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA. [email protected]
  • 2 Department of Neurology Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
  • 3 Departments of Neurology, Radiology & Biomedical Imaging Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, San Francisco, USA.
  • 4 San Francisco Veterans Affairs Health , San Francisco, CA, USA.
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Oct 01, 2021
Volume
15
Issue
5
Pages
2417–2425
Identifiers
DOI: 10.1007/s11682-020-00440-1
PMID: 33432536
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We investigated whether clinically normal older adults with remote, mild traumatic brain injury (mTBI) show evidence of higher cortical Aβ burden. Our study included 134 clinically normal older adults (age 74.1 ± 6.8 years, 59.7% female, 85.8% white) who underwent Aβ positron emission tomography (Aβ-PET) and who completed the Ohio State University Traumatic Brain Injury Identification questionnaire. We limited participants to those reporting injuries classified as mTBI. A subset (N = 30) underwent a second Aβ-PET scan (mean 2.7 years later). We examined the effect of remote mTBI on Aβ-PET burden, interactions between remote mTBI and age, sex, and APOE status, longitudinal Aβ accumulation, and the interaction between remote mTBI and Aβ burden on memory and executive functioning. Of 134 participants, 48 (36%) reported remote mTBI (0, N = 86; 1, N = 31, 2+, N = 17; mean 37 ± 23 years since last mTBI). Effect size estimates were small to negligible for the association of remote mTBI with Aβ burden (p = .94, η2 < 0.01), and for all interaction analyses. Longitudinally, we found a non-statistically significant association of those with remote mTBI (N = 11) having a faster rate of Aβ accumulation (B = 0.01, p = .08) than those without (N = 19). There was no significant interaction between remote mTBI and Aβ burden on cognition. In clinically normal older adults, history of mTBI is not associated with greater cortical Aβ burden and does not interact with Aβ burden to impact cognition. Longitudinal analyses suggest remote mTBI may be associated with more rapid cortical Aβ accumulation. This finding warrants further study in larger and more diverse samples with well-characterized lifelong head trauma exposure. © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

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