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Association of recently described adipokines with liver histology in biopsy-proven non-alcoholic fatty liver disease: a systematic review.

Authors
  • Bekaert, M1
  • Verhelst, X2
  • Geerts, A2
  • Lapauw, B1
  • Calders, P3
  • 1 Department of Endocrinology, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 2 Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 3 Revalidation Science and Physiotherapy, Ghent University Hospital, Ghent, Belgium. , (Belgium)
Type
Published Article
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
Publication Date
Jan 01, 2016
Volume
17
Issue
1
Pages
68–80
Identifiers
DOI: 10.1111/obr.12333
PMID: 26597657
Source
Medline
Keywords
License
Unknown

Abstract

The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, as is the prevalence of obesity and type 2 diabetes. It is increasingly recognized that an impaired pattern in adipokine secretion could play a pivotal role in the development of NAFLD. We performed a systematic review to evaluate the potential link between newly described adipokines and liver histology in biopsy-proven NAFLD patients. A computerized literature search was performed in PubMed, EMBASE and Web of Science electronic databases. Thirty-one cross-sectional studies were included, resulting in a total of seven different investigated adipokines. Studies included in this review mainly had a good methodological quality. Most adipokines were suggested to be involved in the inflammatory response that develops within the context of NAFLD, either at hepatic or systemic level, and/or hepatic insulin resistance. Based on literature, clinical studies suggest that chemerin, resistin and adipocyte-fatty-acid-binding protein potentially are involved in NAFLD pathogenesis and/or progression. However, major inconsistency still exists, and there is a high need for larger studies, together with the need of standardized assays to determine adipokine levels.

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