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Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients.

Authors
  • Feng, X1
  • Li, Y-Z
  • Zhang, Y
  • Bao, S-M
  • Tong, D-W
  • Zhang, S-L
  • Hu, C-J
  • 1 Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China. , (China)
Type
Published Article
Journal
Tissue Antigens
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2010
Volume
76
Issue
4
Pages
297–300
Identifiers
DOI: 10.1111/j.1399-0039.2010.01521.x
PMID: 20604892
Source
Medline
License
Unknown

Abstract

This study aimed at examining the association of the single nucleotide polymorphism (SNP) in the protein tyrosine phosphatase gene (PTPN22) with the risk of rheumatoid arthritis (RA) in a Chinese population. A total of 200 RA patients and age and gender-matched healthy controls were recruited. Their genotypes and allelic frequency were determined by the TaqMan-MGB probe-based polymerase chain reaction (PCR). The frequencies of the CC genotype and C allele in RA patient group were significantly higher than that of controls (P < 0.01 or P < 0.05) with an odds ratio of 1.67, respectively. These data suggest, the CC genotype and C allele of the -1123G > C in the PTPN22 gene are associated with an increased risk for RA in Chinese population. Therefore, the CC genotype and C allele of the -1123G > C in the PTPN22 gene may be used as a genetic marker for the predisposition of RA in Chinese.

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