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Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs.

Authors
  • Meidtner, K
  • Wermter, A-K
  • Hinney, A
  • Remschmidt, H
  • Hebebrand, J
  • Fries, R
Type
Published Article
Journal
Animal genetics
Publication Date
Jun 01, 2006
Volume
37
Issue
3
Pages
245–247
Identifiers
PMID: 16734684
Source
Medline
License
Unknown

Abstract

The melanocortin 4 receptor (MC4R) is a key factor in the regulation of energy balance and body weight. Hence it is a candidate for feed intake and energy homeostasis-related traits. Studies in humans and swine have revealed several sequence variants in the gene that are associated with some of these traits. In pigs the coding non-synonymous missense variant Asp298Asn in MC4R has been associated with feed intake, fatness and growth. Here we confirm the association of this Piétrain-derived polymorphism with feed intake and daily gain in the F2 generation of a Mangalitsa x Piétrain cross. In one Piétrain founder animal, we detected an additional non-synonymous missense variant Arg236His. Thus, the MC4R gene could be a useful marker for increased growth in the relatively slow-growing Piétrain breed.

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