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The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study.

Authors
  • Ong, Yi Lin1
  • Quah, Phaik Ling1
  • Tint, Mya Thway2
  • Aris, Izzuddin M3
  • Chen, Ling Wei3
  • van Dam, Rob M4
  • Heppe, Denise5
  • Saw, Seang-Mei4
  • Godfrey, Keith M6
  • Gluckman, Peter D1
  • Chong, Yap Seng1
  • Yap, Fabian7
  • Lee, Yung Seng1
  • Foong-Fong Chong, Mary1
  • 1 1Singapore Institute for Clinical Sciences,Agency for Science, Technology and Research,Brenner Centre for Molecular Medicine,30 Medical Drive,Singapore 117609,Singapore. , (Singapore)
  • 2 2Department of Obstetrics and Gynaecology,Yong Loo Lin School of Medicine,National University of Singapore and National University Health System,Tower Block, Level 12, 1E Kent Ridge Road,Singapore 119228,Singapore. , (Singapore)
  • 3 3Department of Paediatrics,Yong Loo Lin School of Medicine,National University of Singapore and National University Health System,Tower Block, Level 12, 1E Kent Ridge Road,Singapore 119228,Singapore. , (Singapore)
  • 4 4Saw Swee Hock School of Public Health,National University of Singapore,Tahir Foundation Building, 12 Science Drive 2 #10-01,Singapore 117549,Singapore. , (Singapore)
  • 5 5Department of Pediatrics and of Epidemiology,Erasmus Medical Center,'s-Gravendijkwal 230, 3015 CE Rotterdam,The Netherlands. , (Netherlands)
  • 6 6MRC Lifecourse Epidemiology Unit,NIHR Southampton Biomedical Research Centre,University of Southampton and University Hospital Southampton NHS Foundation Trust,MP 218, Tremona Road,Southampton General Hospital,Southampton SO16 6YD,UK.
  • 7 8Duke-NUS Graduate Medical School,8 College Road, Singapore 169857,Singapore. , (Singapore)
Type
Published Article
Journal
British Journal Of Nutrition
Publisher
Cambridge University Press
Publication Date
Aug 01, 2016
Volume
116
Issue
4
Pages
621–631
Identifiers
DOI: 10.1017/S0007114516000623
PMID: 27339329
Source
Medline
Keywords
License
Unknown

Abstract

Maternal vitamin D status during pregnancy has been associated with infant birth and postnatal growth outcomes, but reported findings have been inconsistent, especially in relation to postnatal growth and adiposity outcomes. In a mother-offspring cohort in Singapore, maternal plasma vitamin D was measured between 26 and 28 weeks of gestation, and anthropometric measurements were obtained from singleton offspring during the first 2 years of life with 3-month follow-up intervals to examine birth, growth and adiposity outcomes. Associations were analysed using multivariable linear regression. Of a total of 910 mothers, 13·2 % were vitamin D deficient (<50 nmol/l) and 26·5 % were insufficient (50-75 nmol/l). After adjustment for potential confounders and multiple testing, no statistically significant associations were observed between maternal vitamin D status and any of the birth outcomes - small for gestational age (OR 1·00; 95 % CI 0·56, 1·79) and pre-term birth (OR 1·16; 95 % CI 0·64, 2·11) - growth outcomes - weight-for-age z-scores, length-for-age z-scores, circumferences of the head, abdomen and mid-arm at birth or postnatally - and adiposity outcomes - BMI, and skinfold thickness (triceps, biceps and subscapular) at birth or postnatally. Maternal vitamin D status in pregnancy did not influence infant birth outcomes, postnatal growth and adiposity outcomes in this cohort, perhaps due to the low prevalence (1·6 % of the cohort) of severe maternal vitamin D deficiency (defined as of <30·0 nmol/l) in our population.

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