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Association of leptin genetic polymorphism -2548 G/A with gestational diabetes mellitus

Authors
  • Vaškú, Julie Anna Bienertová1
  • Vaškú, Anna1
  • Dostálová, Zuzana2
  • Bienert, Petr1
  • 1 Masaryk University, Institute of Pathological Physiology, Faculty of Medicine, Brno, 662 43, Czech Republic , Brno (Czechia)
  • 2 Masaryk University affiliated Hospital, Clinic of Obstetrics and Gynecology, Brno, 602 00, Czech Republic , Brno (Czechia)
Type
Published Article
Journal
Genes & Nutrition
Publisher
Springer-Verlag
Publication Date
Jun 01, 2006
Volume
1
Issue
2
Pages
117–123
Identifiers
DOI: 10.1007/BF02829953
Source
Springer Nature
Keywords
License
Yellow

Abstract

The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GGgenotype(OR=2.84, 95%CI1.14–7.07,p=0.02). Thereisa significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02–3.14, p=0.03). Furthermore, evaluations of preeclamptic patients’ data revealed a significant association of genotype distribution and delivery and spontaneous abortion rate, where the GG carriers performed the highest pregnancy rate while the AG carriers performed the lowest spontaneous abortion rate. Our results support the hypothesis for -2548 G/A leptin gene polymorphism involvement in ethiopathogenesis of pregnancy-associated diseases with abnormal fetal growth, especially gestational diabetes mellitus.

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