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Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features.

Authors
  • Marques, Diego1
  • Ferreira-Costa, Layse Raynara1
  • Ferreira-Costa, Lorenna Larissa1
  • Correa, Romualdo da Silva2
  • Borges, Aline Maciel Pinheiro2
  • Ito, Fernanda Ribeiro2
  • Ramos, Carlos Cesar de Oliveira3
  • Bortolin, Raul Hernandes1
  • Luchessi, André Ducati1
  • Ribeiro-Dos-Santos, Ândrea4
  • Santos, Sidney4
  • Silbiger, Vivian Nogueira1
  • 1 Laboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil. , (Brazil)
  • 2 Departamento de Cirurgia Oncológica, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil. , (Brazil)
  • 3 Laboratório de Patologia e Citopatologia, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil. , (Brazil)
  • 4 Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66055-080, Pará, Brazil. , (Brazil)
Type
Published Article
Journal
World journal of gastroenterology
Publication Date
Oct 07, 2017
Volume
23
Issue
37
Pages
6854–6867
Identifiers
DOI: 10.3748/wjg.v23.i37.6854
PMID: 29085228
Source
Medline
Keywords
License
Unknown

Abstract

The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings.

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