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Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus

Authors
  • Witte, T.1
  • Hartung, K.2
  • Matthias, T.3
  • Sachse, C.4
  • Fricke, M.1
  • Deicher, H.1
  • Kalden, J. R.5
  • Lakomek, H. J.6
  • Peter, H. H.7
  • Schmidt, R. E.1
  • 1 Members of the SLE Study Group Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany Fax: 01149-511-5325648; e-mail: [email protected], DE
  • 2 Institut für Laboratoriums- und Transfusionsmedizin, Zentralkrankenhaus Reinkenheide, Postbrookstr. 103, D-27574 Bremerhaven, Germany, DE
  • 3 ORGenTec Diagnostika GmbH, Kupferbergterrasse 17 – 19, D-55116 Mainz, Germany, DE
  • 4 Abteilung Klinische Chemie II, Medizinische Hochschule Hannover, Podbielskistr. 380, D-30659 Hannover, Germany, DE
  • 5 Medizinische Klinik III der FAU Erlangen-Nürnberg, Krankenhausstr. 12, D-91054 Erlangen, Germany, DE
  • 6 Klinik für Rheumatologie und Physikalische Medizin, Friedrichstr. 17, D-32427 Minden, Germany, DE
  • 7 Medizinische Universitätsklinik, Abteilung Rheumatologie und Klinische Immunologie, Hugstetter Str. 55, D-79106 Freiburg, Germany, DE
Type
Published Article
Journal
Rheumatology International
Publisher
Springer-Verlag
Publication Date
Aug 01, 1998
Volume
18
Issue
2
Pages
63–69
Identifiers
DOI: 10.1007/s002960050059
Source
Springer Nature
Keywords
License
Yellow

Abstract

Previously it has been suggested that the presence of antibodies against dsDNA of the IgA class may define a subset of systemic lupus erythematosus (SLE) patients suffering from nephritis and arthritis. Therefore, these autoantibodies were measured in sera of 352 patients with SLE, 81 blood donors, and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgA anti-dsDNA antibodies were found in 19.9% of the sera from patients with SLE, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 36 laboratory parameters was calculated. IgA anti-dsDNA antibodies were found to be associated with parameters of disease activity such as elevated erythrocyte sedimentation rate and consumption of complement component C3, and the clinical parameters vasculitis, acral necrosis and erythema, but not with nephritis and arthritis. Therefore, IgA anti-dsDNA antibodies define a subset of SLE patients, and monitoring of IgA anti-dsDNA antibodies may be helpful as a prognostic parameter in patients with SLE.

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