Affordable Access

Access to the full text

Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population

Authors
  • Ocejo-Vinyals, J. Gonzalo
  • Gonzalez-Gay, Miguel A.1
  • Fernández-Viña, Marcelo A.
  • Cantos-Mansilla, Juan
  • Vilanova, Iosune2
  • Blanco, Ricardo1
  • González-López, Marcos A.2
  • 1 (R.B.)
  • 2 (M.A.G.-L)
Type
Published Article
Journal
Journal of Clinical Medicine
Publisher
MDPI AG
Publication Date
Sep 25, 2020
Volume
9
Issue
10
Identifiers
DOI: 10.3390/jcm9103095
PMID: 32992947
PMCID: PMC7600823
Source
PubMed Central
Keywords
License
Green

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease of the hair follicle typically presenting recurrent, painful, and inflamed lesions on the inverse areas of the body. Although its pathogenesis remains unknown, the immune system appears to play a potential role. To date, two previous studies have not found any association between the Human Leukocyte Antigen system (HLA) and HS. In this study we analyzed the HLA-A , -B, -C ; and DRB1 , - DQA1, and –DQB1 allele distribution in 106 HS patients and 262 healthy controls from a Caucasian population in Cantabria (northern Spain). HLA-A *29 and B *50 were significantly more common in HS patients and A *30 and B *37 in controls, but these associations disappeared after statistical correction. DRB1 *07, DQA1 *02, and DQB1 *02 were significantly more common in controls ( p 0.026, p 0.0012, and p 0.0005, respectively) and the HLA allele DQB1 *03:01 was significantly more common in HS patients ( p 0.00007) after the Bonferroni correction. The DRB1*07~DQA1*02~DQB1*02 haplotype was significantly more common in controls ( p < 0.0005). This is the first study showing an association between HLA-class II and HS. Our results suggest that HLA-II alleles ( DRB1 *07, DQA1 *02, DQB1 *02, and DQB1 *03:01) and the DRB1 *07~ DQA1 *02~ DQB1 *02 haplotype could influence resistance or susceptibility to HS.

Report this publication

Statistics

Seen <100 times