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Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction.

Authors
  • Chen, Tingting1
  • Blanc, Caroline1
  • Eder, Anke Z1
  • Prados-Rosales, Rafael2
  • Souza, Ana Camila Oliveira2
  • Kim, Ryung S3
  • Glatman-Freedman, Aharona4
  • Joe, Maju5
  • Bai, Yu5
  • Lowary, Todd L5
  • Tanner, Rachel6
  • Brennan, Michael J7
  • Fletcher, Helen A6
  • McShane, Helen6
  • Casadevall, Arturo8
  • Achkar, Jacqueline M9
  • 1 Department of Medicine.
  • 2 Department of Microbiology and Immunology.
  • 3 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx.
  • 4 Department of Pediatrics Department of Family and Community Medicine, New York Medical College, Valhalla, New York Infectious Diseases Unit, Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer.
  • 5 Alberta Glycomics Centre Department of Chemistry, University of Alberta, Edmonton, Canada.
  • 6 Jenner Institute, University of Oxford, United Kingdom.
  • 7 Aeras, Rockville.
  • 8 Department of Medicine Department of Microbiology and Immunology Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • 9 Department of Medicine Department of Microbiology and Immunology.
Type
Published Article
Journal
The Journal of Infectious Diseases
Publisher
Oxford University Press
Publication Date
Jul 15, 2016
Volume
214
Issue
2
Pages
300–310
Identifiers
DOI: 10.1093/infdis/jiw141
PMID: 27056953
Source
Medline
Keywords
License
Unknown

Abstract

Our results provide further evidence for a role of Ab-mediated immunity to tuberculosis and suggest that IgG to AM, especially to some of its OS epitopes, could contribute to the defense against mycobacterial infection in humans.

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