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Association of HIV Infection with Epilepsy and Other Comorbid Conditions.

Authors
  • Cattaneo, Dario1, 2
  • Giacomelli, Andrea3
  • Minisci, Davide3
  • Astuti, Noemi3
  • Meraviglia, Paola3
  • Gervasoni, Cristina4, 5
  • 1 Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy. , (Italy)
  • 2 Unit of Clinical Pharmacology, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy. , (Italy)
  • 3 Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Via GB Grassi 74, 20157, Milan, Italy. , (Italy)
  • 4 Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy. [email protected] , (Italy)
  • 5 Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Via GB Grassi 74, 20157, Milan, Italy. [email protected] , (Italy)
Type
Published Article
Journal
AIDS and Behavior
Publisher
Springer-Verlag
Publication Date
Apr 01, 2020
Volume
24
Issue
4
Pages
1051–1055
Identifiers
DOI: 10.1007/s10461-019-02530-8
PMID: 31054031
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Here, we aimed to investigate the associations of comorbidities in HIV patients given antiepileptic drugs. HIV patients given antiepileptic drugs for at least 6 months were considered. Comorbidities of the epileptic, HIV-positive patients were stratified according to patients' age and causes of epilepsy. Seventy-four of the 97 HIV patients identified had at least one comorbidity. Patients more than 50-years old had more comorbidities (1.9 ± 1.5 vs. 1.1 ± 1.2, p < 0.01) compared with younger subjects. The distribution of the psychiatric disorders was comparable between age-related categories. A marginally significant trend for higher frequency of psychiatric disorders was observed in patients with idiopathic epilepsy versus other causes of epilepsy (43% vs. 24%), Because the presence of comorbid disorders is a major driver for premature mortality both in HIV infection and epilepsy, strategies aimed at favoring prevention, early identification, and adequate treatment in these clinical settings should be pursued at all levels of care.

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