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Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.

Authors
  • Chapman, Andrew R1
  • Lee, Kuan Ken1
  • McAllister, David A2
  • Cullen, Louise3, 4, 5
  • Greenslade, Jaimi H3, 4, 5
  • Parsonage, William3, 4, 5
  • Worster, Andrew6
  • Kavsak, Peter A7
  • Blankenberg, Stefan8
  • Neumann, Johannes8
  • Söerensen, Nils A8
  • Westermann, Dirk8
  • Buijs, Madelon M9
  • Verdel, Gerard J E10
  • Pickering, John W11, 12
  • Than, Martin P12
  • Twerenbold, Raphael13
  • Badertscher, Patrick13
  • Sabti, Zaid13
  • Mueller, Christian13
  • And 17 more
  • 1 BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.
  • 2 Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland.
  • 3 Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. , (Australia)
  • 4 School of Medicine, University of Queensland, Brisbane, Australia. , (Australia)
  • 5 Faculty of Health, Queensland University of Technology, Brisbane, Australia. , (Australia)
  • 6 Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
  • 7 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
  • 8 University Heart Center, Hamburg, Germany. , (Germany)
  • 9 Atalmedial Diagnostic Centers, Hoofddorp, the Netherlands. , (Netherlands)
  • 10 Department of Cardiology, Spaarne Gasthuis, Haarlem, the Netherlands. , (Netherlands)
  • 11 Department of Medicine, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 12 Emergency Department, Christchurch Hospital, Christchurch, New Zealand. , (New Zealand)
  • 13 Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital, Basel, Switzerland. , (Switzerland)
  • 14 Department of Emergency Medicine and EMERGE, Royal Infirmary of Edinburgh, Edinburgh, Scotland.
  • 15 Central Manchester University Hospitals NHS Foundation Trust and the University of Manchester, Manchester, England.
  • 16 University Hospital South Manchester NHS Foundation Trust, Manchester, England.
  • 17 Department of Emergency Medicine, Southmead Hospital, Bristol, England.
  • 18 Department of Cardiology, Sunshine Coast University Hospital, University of the Sunshine Coast, Birtinya, Australia. , (Australia)
  • 19 University of Michigan Medical School, Ann Arbor.
  • 20 John Hopkins School of Medicine, Baltimore, Maryland.
  • 21 Hennepin County Medical Center and Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
  • 22 Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis.
Type
Published Article
Journal
JAMA
Publisher
American Medical Association
Publication Date
Nov 21, 2017
Volume
318
Issue
19
Pages
1913–1924
Identifiers
DOI: 10.1001/jama.2017.17488
PMID: 29127948
Source
Medline
License
Unknown

Abstract

Among patients with suspected acute coronary syndrome, a high-sensitivity cardiac troponin I concentration of less than 5 ng/L identified those at low risk of myocardial infarction or cardiac death within 30 days. Further research is needed to understand the clinical utility and cost-effectiveness of this approach to risk stratification.

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