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Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.

  • Chapman, Andrew R1
  • Lee, Kuan Ken1
  • McAllister, David A2
  • Cullen, Louise3, 4, 5
  • Greenslade, Jaimi H3, 4, 5
  • Parsonage, William3, 4, 5
  • Worster, Andrew6
  • Kavsak, Peter A7
  • Blankenberg, Stefan8
  • Neumann, Johannes8
  • Söerensen, Nils A8
  • Westermann, Dirk8
  • Buijs, Madelon M9
  • Verdel, Gerard J E10
  • Pickering, John W11, 12
  • Than, Martin P12
  • Twerenbold, Raphael13
  • Badertscher, Patrick13
  • Sabti, Zaid13
  • Mueller, Christian13
  • And 17 more
  • 1 BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.
  • 2 Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland.
  • 3 Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia. , (Australia)
  • 4 School of Medicine, University of Queensland, Brisbane, Australia. , (Australia)
  • 5 Faculty of Health, Queensland University of Technology, Brisbane, Australia. , (Australia)
  • 6 Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
  • 7 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. , (Canada)
  • 8 University Heart Center, Hamburg, Germany. , (Germany)
  • 9 Atalmedial Diagnostic Centers, Hoofddorp, the Netherlands. , (Netherlands)
  • 10 Department of Cardiology, Spaarne Gasthuis, Haarlem, the Netherlands. , (Netherlands)
  • 11 Department of Medicine, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 12 Emergency Department, Christchurch Hospital, Christchurch, New Zealand. , (New Zealand)
  • 13 Cardiovascular Research Institute Basel and Department of Cardiology, University Hospital, Basel, Switzerland. , (Switzerland)
  • 14 Department of Emergency Medicine and EMERGE, Royal Infirmary of Edinburgh, Edinburgh, Scotland.
  • 15 Central Manchester University Hospitals NHS Foundation Trust and the University of Manchester, Manchester, England.
  • 16 University Hospital South Manchester NHS Foundation Trust, Manchester, England.
  • 17 Department of Emergency Medicine, Southmead Hospital, Bristol, England.
  • 18 Department of Cardiology, Sunshine Coast University Hospital, University of the Sunshine Coast, Birtinya, Australia. , (Australia)
  • 19 University of Michigan Medical School, Ann Arbor.
  • 20 John Hopkins School of Medicine, Baltimore, Maryland.
  • 21 Hennepin County Medical Center and Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota.
  • 22 Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis.
Published Article
American Medical Association
Publication Date
Nov 21, 2017
DOI: 10.1001/jama.2017.17488
PMID: 29127948


Among patients with suspected acute coronary syndrome, a high-sensitivity cardiac troponin I concentration of less than 5 ng/L identified those at low risk of myocardial infarction or cardiac death within 30 days. Further research is needed to understand the clinical utility and cost-effectiveness of this approach to risk stratification.

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