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Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis

Authors
  • Kpoghomou, Marce-Amara1, 1
  • Wang, Jinchen1, 1
  • Wang, Tianpei1, 1
  • Jin, Guanfu1, 1
  • 1 Nanjing Medical University, Nanjing, 211166, China , Nanjing (China)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 24, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12885-020-06962-7
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.MethodsCase-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of H. pylori babA2 gene associated with GC risk.ResultsTwenty studies were identified with a total of 1289 GC cases and 1081 controls. H. pylori babA2 gene was associated with an increased risk of GC by 2.05 fold (95% CI, 1.30–3.24, P = 0.002). In subgroup analysis, we found that H. pylori babA2 gene was significantly associated with GC risk in Asian population (OR = 2.63, 95% CI: 1.36–5.09 P = 0.004) but not in South American population (OR = 1.35, 95% CI: 0.69–2.64, P = 0.379).ConclusionsThis meta-analysis indicates that H. pylori babA2 gene may be associated with increased risk of GC, especially in Asian population.

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