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The association of estrogen-signaling pathways and susceptibility to open-angle glaucoma

Authors
  • Ulhaq, Zulvikar Syambani1
  • 1 Maulana Malik Ibrahim Islamic State University of Malang, Batu, East Java, 65151, Indonesia , Batu (Indonesia)
Type
Published Article
Journal
Beni-Suef University Journal of Basic and Applied Sciences
Publisher
Springer Berlin Heidelberg
Publication Date
Feb 20, 2020
Volume
9
Issue
1
Identifiers
DOI: 10.1186/s43088-020-0034-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundGlaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration. Evidence suggests the role of estradiol (E2) and the etiology of glaucoma. Therefore, this present study evaluates the association between estrogen-signaling pathways and the risk of open-angle glaucoma (OAG).ResultsMeta-analysis was performed from available studies that investigated intraocular pressure (IOP) in patients treated with or without hormone replacement therapy (HRT) and studies that evaluated the associations between estrogen receptor (ER) polymorphisms and the risk of OAG. The pooled result showed that HRT had a positive effect in lowering IOP. Moreover, ERβ polymorphisms showed a significant association with the risk of OAG.ConclusionThis report supports the notion that estrogen-signaling pathways play a pivotal role in the development of OAG.

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