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Association of breast cancer and meningioma. Report of 12 new cases and review of the literature.

Authors
  • Bonito, D
  • Giarelli, L
  • Falconieri, G
  • Bonifacio-Gori, D
  • Tomasic, G
  • Vielh, P
Type
Published Article
Journal
Pathology - Research and Practice
Publisher
Elsevier
Publication Date
May 01, 1993
Volume
189
Issue
4
Pages
399–404
Identifiers
PMID: 8351240
Source
Medline
License
Unknown

Abstract

We report 12 new cases of female breast cancer associated with intracranial meningiomas, inclusive of autopsy study. At the time of death the patients' age ranged from 52 to 95 years (average 70.6 years). Breast carcinomas were documented ante mortem in 11 cases and at autopsy in 1. Meningiomas were diagnosed at autopsy (10 cases) or in vivo (2 cases). The diagnosis of meningioma antedated that of mammary carcinoma in only one patient. Histologically, the cancers were of ductal (11 cases) and lobular infiltrating (1 case) types and showed a variable malignancy grade. Widespread extracranial metastases were present at autopsy in 7 cases. Brain metastases were seen in 1 case. Neurologic signs were referred in 4 subjects. Four breast cancers and one meningioma showed immunoreactivity for progesterone receptors, whereas all the cases were negative for estrogen receptors. In one case, metastatic breast carcinoma tissue was present within a psammomatous meningioma. A brief review of the literature, which includes 14 similar observations, is reported. Although the association of breast cancer and meningioma is still difficult to explain, its clinical implications are important and deserve proper attention. A proper work up in patients with suspected intracranial metastases is recommended so that resectable meningiomas are not mistaken for metastases.

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