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Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children.

Authors
  • Georgieva, V1
  • Kamolvit, W2
  • Herthelius, M1
  • Lüthje, P2
  • Brauner, A2
  • Chromek, M1, 3
  • 1 Department of Clinical Science, Intervention and Technology, Division of Paediatrics, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. , (Sweden)
  • 2 Department of Microbiology, Tumour and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. , (Sweden)
  • 3 Department of Clinical Sciences Lund, Division of Paediatrics, Lund University, Lund, Sweden. , (Sweden)
Type
Published Article
Journal
Acta Paediatrica
Publisher
Wiley (Blackwell Publishing)
Publication Date
Mar 01, 2019
Volume
108
Issue
3
Pages
551–556
Identifiers
DOI: 10.1111/apa.14499
PMID: 30003595
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection (UTI). The study included 120 children under three years of age: 76 children with UTIs and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay. We found that vitamin D insufficiency and deficiency are prevalent in young children (21%). Serum vitamin D levels negatively correlated with age and were significantly lower in girls. Levels of vitamin D positively correlated with levels of cathelicidin but not with β-defensin-2. Low concentrations of vitamin D were associated with UTIs in girls, but we did not see any correlation with the recurrence of infection at one-year follow-up. Vitamin D deficiency is common and may prove to be a risk factor for UTIs especially in girls. We hypothesise that adequate supplementation with vitamin D may become a way to prevent first-time UTIs. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

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