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The association between sonographic enthesitis and radiographic damage in psoriatic arthritis

Authors
  • Polachek, Ari1
  • Cook, Richard2
  • Chandran, Vinod3, 4, 5
  • Gladman, Dafna D.6
  • Eder, Lihi7
  • 1 Toronto Western Hospital, University of Toronto, Centre for Prognostic Studies in the Rheumatic Diseases, 1-412, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada , Toronto (Canada)
  • 2 University of Waterloo, Department of Statistics and Actuarial Science, Waterloo, ON, Canada , Waterloo (Canada)
  • 3 University of Toronto, Department of Medicine and Laboratory Medicine, Institute of Medical Science, Toronto, ON, Canada , Toronto (Canada)
  • 4 University of Toronto, Department of Pathobiology, Institute of Medical Science, Toronto, ON, Canada , Toronto (Canada)
  • 5 Toronto Western Hospital, Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, Toronto, ON, Canada , Toronto (Canada)
  • 6 Center for Prognostic Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada , Toronto (Canada)
  • 7 University of Toronto, Women’s College Research Institute, Women’s College Hospital, Department of Medicine, Room 6326, 76 Grenville Street, Toronto, ON, M5S 1B2, Canada , Toronto (Canada)
Type
Published Article
Journal
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Publication Date
Aug 15, 2017
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s13075-017-1399-5
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundTo examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA).MethodsA cross-sectional analysis was conducted in patients with PsA. The MAdrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities. Radiographic damage in the peripheral joints and spine was assessed by the modified Steinbrocker score (mSS), Modified New York Criteria for sacroiliitis, and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The association between MASEI and the extent of radiographic damage was assessed using negative binomial and logistic regression. The results were expressed in terms of the regression coefficient estimates and their exponentiated values (eβ) or odds ratios (OR), and 95% confidence intervals (CI).ResultsTwo hundred and twenty three patients were analyzed; 58% were males, with mean ± SD age of 55.9 ± 12.9 years and PsA duration of 16.7 ± 12.4 years. Regression analyses yielded an association between higher MASEI scores (10 units increase) and peripheral joint damage including mSS (eβ = 1.42, 95% CI: 1.15, 1.72), joint ankylosis (OR = 1.93, 95% CI: 1.37, 2.72), arthritis mutilans (OR = 1.77, 95% CI: 1.23, 2.54), and periostitis (OR = 1.41, 95% CI: 1.08, 1.84). Similarly, an association was found between higher MASEI scores and axial damage as measured by mSASSS (eβ = 2.18, 95% CI: 1.16, 4.09) and sacroiliitis (OR = 1.33, 95% CI: 1.03, 1.72).ConclusionsThe severity of sonographic enthesitis is a potential marker of radiographic peripheral and axial joint damage in PsA.

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