Sexual minority men have reported higher rates of both indoor tanning and skin cancer than heterosexual men, and sexual minority women have reported lower or equal rates of both indoor tanning and skin cancer compared with heterosexual women. Bisexual men, in particular, have reported higher rates of indoor tanning bed use than heterosexual men; however, no study has investigated skin cancer prevalence among gay, lesbian, and bisexual individuals as separate groups. To evaluate the association between sexual orientation and lifetime prevalence of skin cancer. This cross-sectional study analyzed data from the 2014-2018 Behavioral Risk Factor Surveillance System (BRFSS) surveys of a noninstitutionalized population in the United States that included 845 264 adult participants who self-identified as being heterosexual, gay, lesbian, or bisexual. Self-reported lifetime history of skin cancer. The study included 845 264 participants, including 351 468 heterosexual men (mean age, 47.7; 95% CI, 47.5-47.8), 7516 gay men (mean age, 42.7; 95% CI, 41.9-43.5), 5088 bisexual men (mean age, 39.3; 95% CI, 38.2-40.4), 466 355 heterosexual women (mean age, 49.7; 95% CI, 49.6-49.9), 5392 lesbian women (mean age, 41.9; 95% CI, 40.7-43.2), and 9445 bisexual women (mean age, 32.7; 95% CI, 32.2-33.2). The adjusted odds ratios (AORs) of skin cancer prevalence were significantly higher among both gay (AOR, 1.26; 95% CI, 1.05-1.51; P = .01) and bisexual men (AOR, 1.48; 95% CI, 1.02-2.16; P = .04) compared with heterosexual men. The AORs of skin cancer were statistically significantly lower among bisexual women (AOR, 0.78; 95% CI, 0.61-0.99; P = .04) but not among gay or lesbian women (AOR, 0.97; 95% CI, 0.73-1.27; P = .81) compared with the AORs of skin cancer among heterosexual women. In this study, gay and bisexual men had an increased self-reported lifetime prevalence of skin cancer compared with the prevalence among heterosexual men. Patient education and community outreach initiatives focused on reducing skin cancer risk behaviors among gay and bisexual men may help reduce the lifetime development of skin cancer in this population. Continued implementation of the Behavioral Risk Factor Surveillance System's sexual orientation and gender identity module is imperative to improve understanding of the health and well-being of sexual minority populations.