Affordable Access

deepdyve-link
Publisher Website

There is an association between serum high-sensitivity C-reactive protein (hs-CRP) concentrations and depression score in adolescent girls.

Authors
  • Tabatabaeizadeh, Seyed-Amir1
  • Abdizadeh, Mojtaba Fattahi2
  • Meshkat, Zahra3
  • Khodashenas, Ezzat4
  • Darroudi, Susan5
  • Fazeli, Mostafa5
  • Ferns, Gordon A6
  • Avan, Amir7
  • Ghayour-Mobarhan, Majid8
  • 1 Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 2 Department of Microbiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. , (Iran)
  • 3 Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 4 Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , (Iran)
  • 5 Metabolic Syndrome Research Center, Mashhad University of Medical Science, Mashhad, Iran. , (Iran)
  • 6 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
  • 7 Metabolic Syndrome Research Center, Mashhad University of Medical Science, Mashhad, Iran; Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Electronic address: [email protected] , (Iran)
  • 8 Metabolic Syndrome Research Center, Mashhad University of Medical Science, Mashhad, Iran; Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Psychoneuroendocrinology
Publication Date
Feb 01, 2018
Volume
88
Pages
102–104
Identifiers
DOI: 10.1016/j.psyneuen.2017.11.014
PMID: 29197794
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Whilst there is evidence of an association between depression and inflammation in adults, there is limited data on this in adolescents particularly in non-westernized populations. ‎ The primary aim of this study was to evaluate the association between serum hs-CRP level and depression ‎score in adolescent girls living in northwestern Iran. Serum hs-CRP was measured in 563 adolescent girls aged 12-18 years. Depression score was assessed using the Beck's depression inventory II (BDI-II).‎ RESULTS: Serum hs-CRP was 0.61 (0.30-0.88) mg/L [median (interquartile range)] in the non-depressed group, 0.97 (0.50-1.82) mg/L in the group with a mild depression score, 1.04 (0.57-1.60) mg/L in those with a moderate depression score, and 0.84 (0.45-2.64) mg/L in girls with severe depression (Kruskal-Wallis test, P<0.001). It has shown that hs-CRP is significantly higher in depressed groups. Multinomial logistic regression analysis, controlling for age, BMI, waist circumference, social class, alcohol consumption, smoking or being passive smoker and recent infections, showed that depression scores were positively associated with serum hs-CRP level (OR=1.93, P<0.001). Using a linear model after adjustment, B (the unstandardized beta) of hs-CRP according to the depression score was 1.43, P<0.001. There is a significant association between serum hs-CRP and depression score in adolescent girls. The cross sectional study design does not allow us to conclude that there is a direct relationship between inflammation and depression, and this would need to be tested in an intervention study. Copyright © 2017 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times