Affordable Access

Access to the full text

Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

Authors
  • Choi, Jung Ran1
  • Jeon, Minhee1
  • Koh, Sang Baek1, 1
  • 1 Yonsei University Wonju College of Medicine, Wonju, Republic of Korea , Wonju (South Korea)
Type
Published Article
Journal
BMC Medical Genetics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 06, 2020
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12881-019-0927-3
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundHypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension.MethodsWe carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped.ResultsIn hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m2, respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101–1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018–2.056; p for trend = 0.040) in cohort A.ConclusionsHTR2A genetic variations were associated with hypertension risk in our study.

Report this publication

Statistics

Seen <100 times