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Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori.

Authors
  • Lin, D B
  • Tsai, T P
  • Yang, C C
  • Wang, H M
  • Nieh, W T
  • Ling, U P
  • Changlai, S P
  • You, S L
  • Ho, M S
  • Chen, C J
Type
Published Article
Journal
The American journal of tropical medicine and hygiene
Publication Date
Jan 01, 2000
Volume
63
Issue
3-4
Pages
189–191
Identifiers
PMID: 11388513
Source
Medline
License
Unknown

Abstract

Helicobacter pylori and hepatitis A virus (HAV) are documented to share common transmission routes including fecal-oral. This study examined the association between seropositivity of antibodies against H. pylori (anti-HP) and HAV (anti-HAV) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. Serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-HP by enzyme-linked immunosorbent assay, and for anti-HAV by microparticle enzyme immunoassay. In children, a low prevalence of anti-HAV (0.44%) was found, in contrast to a high prevalence in their teachers (78.8%); anti-HP seroprevalence was 6.4% for children and 30.8% for teachers. Anti-HAV and anti-HP seropositivities were significantly associated in teachers after adjustment for age, sex, and residential area through multiple logistic regression analysis (multivariate-adjusted odds ratio = 7.3; 95% confidence interval [CI] = 1.4-36.8, P < 0.001). Our findings suggest that HAV and H. pylori may have shared transmission routes in central Taiwan 15 years or more ago, but not any recently.

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