Affordable Access

deepdyve-link
Publisher Website

The association between red cell distribution width and clinical outcomes in patients hospitalised due to chest pain.

Authors
  • Topaz, Guy1, 2
  • Yeruchimovich, Michael1, 2
  • Pereg, David2, 3
  • Eitan, Mayan1, 2
  • Kitay-Cohen, Yona1, 2
  • Hammer, Yoav2, 4
  • Itzhaki Ben Zadok, Osnat2, 4
  • Eisen, Alon2, 4
  • 1 Department of Internal Medicine C, Meir Medical Center , Kfar Saba , Israel. , (Israel)
  • 2 Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel. , (Israel)
  • 3 Department of Cardiology, Meir Medical Center , Kfar Saba , Israel. , (Israel)
  • 4 Department of Cardiology, Rabin Medical Center , Petah Tikva , Israel. , (Israel)
Type
Published Article
Journal
Acta cardiologica
Publication Date
Oct 01, 2019
Volume
74
Issue
5
Pages
413–418
Identifiers
DOI: 10.1080/00015385.2018.1521055
PMID: 30650021
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background: Red blood cell distribution width (RDW) is a measure of the degree of heterogeneity of erythrocyte volume. Higher RDW levels are associated with increased mortality among patients with acute coronary syndrome (ACS), heart failure and other cardiovascular diseases. The association between RDW levels and clinical outcomes in patients admitted for further evaluation of chest pain is not known. Methods: A retrospective analysis of patients hospitalised with chest pain 2010-2016 was conducted. Patients diagnosed with ACS in the emergency department (ED) were excluded. Patients were divided into tertiles according to baseline ED RDW levels (≤13.1%, 13.1%<RDW ≤13.9%, >13.9%). Study endpoints were diagnosis of ACS during the index hospitalisation and ACS and all-cause mortality during a median follow-up of 3.3 ± 1.9 years. Results: Included were 13,018 patients (mean age 58 ± 13 years, 61% male). Increased RDW levels were associated with higher rates of ACS in the index hospitalisation (6.1%, 6.6% and 8.1% for 1st, 2nd and 3rd tertiles, respectively, p < .01), ACS during follow-up (8.6%, 10.1% and 13.4%, respectively, p < .01), and with all-cause mortality during follow-up (2.5%, 4.6% and 15.4%, respectively, p < .01). In multivariate analysis, RDW levels >13.9% (vs. ≤13.1%) were associated with ACS in the index hospitalisation (adjusted OR 1.25, 95% CI 1.04-1.51, p = .02), ACS during follow-up (adjusted OR 1.35, 95% CI 1.05-1.73, p = .02) and with all-cause mortality (adjusted HR 2.41, 95% CI 1.94-2.99, p < .01). Conclusion: In this retrospective study of patients hospitalised with chest pain, higher RDW levels were associated with future ACS and long-term mortality.

Report this publication

Statistics

Seen <100 times