Affordable Access

deepdyve-link
Publisher Website

Association between PPARalpha gene polymorphisms and myocardial infarction.

Authors
  • Reinhard, Wibke
  • Stark, Klaus
  • Sedlacek, Kamil
  • Fischer, Marcus
  • Baessler, Andrea
  • Neureuther, Katharina
  • Weber, Stefan
  • Kaess, Bernhard
  • Wiedmann, Silke
  • Mitsching, Stefan
  • Lieb, Wolfgang
  • Erdmann, Jeanette
  • Meisinger, Christa
  • Doering, Angela
  • Tolle, Ralf
  • Jeron, Andreas
  • Riegger, Guenter
  • Hengstenberg, Christian
Type
Published Article
Journal
Clinical Science
Publisher
Portland Press
Publication Date
Nov 01, 2008
Volume
115
Issue
10
Pages
301–308
Identifiers
DOI: 10.1042/CS20070391
PMID: 18336366
Source
Medline
License
Unknown

Abstract

PPARalpha (peroxisome-proliferator-activated receptor alpha) regulates the expression of genes that are involved in lipid metabolism, tissue homoeostasis and inflammation. Consistent rodent and human studies suggest a link between PPARalpha function and cardiovascular disease, qualifying PPARalpha [PPARA in HUGO (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPARalpha gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium within the PPARalpha gene in an initial case-control sample of 806 individuals from the Regensburg Myocardial Infarction Family Study using a panel of densely spaced SNPs (single nucleotide polymorphisms) across the gene. Single SNP analysis showed significant association with the disease phenotype [OR (odds ratio)=0.74, P=0.012, 95% CI (confidence interval)=0.61-0.94 for rs135551]. Moreover, we identified a protective three-marker haplotype with an association trend for myocardial infarction (OR=0.76, P=0.067, 95% CI=0.56-1.02). Subsequently, we were able to confirm the single SNP and haplotype association results in an independent second case-control cohort with 667 cases from the Regensburg Myocardial Infarction Family Study and 862 control individuals from the WHO (World Health Organization) MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Augsburg project (OR=0.87, P=0.046, 95% CI=0.72-0.99 for rs135551 and OR=0.80, P=0.034, 95% CI=0.65-0.98 for the three-marker haplotype respectively). From these cross-sectional association results, we provide evidence that common variations in the PPARalpha gene may influence the risk of myocardial infarction in a European population.

Report this publication

Statistics

Seen <100 times