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Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.

Authors
  • Sun, Yu-Xiao1
  • Gao, Chuan-Yu2
  • Lu, Yang3
  • Fu, Xin4
  • Jia, Jun-Ge1
  • Zhao, Yu-Jie1
  • Li, Lian-Dong1
  • Dui, Hong-Zhi1
  • Zhang, Xing-Yu1
  • Li, Zhi-Ying1
  • Lei, Lei1
  • Zhang, Wei-Feng1
  • Yuan, Yi-Qiang1
  • 1 Department of Cardiology, The Seventh People's Hospital, Zhengzhou, Henan, 450016, China. , (China)
  • 2 Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou, 450000, China. , (China)
  • 3 Department of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. , (China)
  • 4 Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. , (China)
Type
Published Article
Journal
Oncotarget
Publisher
"Impact Journals, LLC "
Publication Date
Feb 21, 2017
Volume
8
Issue
8
Pages
13166–13173
Identifiers
DOI: 10.18632/oncotarget.14486
PMID: 28061459
Source
Medline
Keywords
License
Unknown

Abstract

Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066-1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the "GC" haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population.

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